Protein Modification Reagents
Medchemexpress LLC MAK683-CH2CH2COOH hydrochloride | 00-00-0 | 99.6% | 484.91 g·mol⁻¹ | C23H22ClFN6O3 | 5 MG
MAK683-CH2CH2COOH hydrochloride is a PROTAC linker supplied as a high-purity solid for research use. It binds to the EED protein and has been used with an E3 ligase ligand to design PROTAC degraders. Handle and store under recommended conditions to preserve stability and activity.
- Binds to EED (embryonic ectoderm development protein).
- High purity: 99.6%.
- Molecular weight: 484.91 g·mol⁻¹.
- Physical form: solid, white to light yellow.
- Storage: keep refrigerated at 4°C and protect from light; store under inert gas for long-term stability.
- Available in small milligram packages for research workflows.
Medchemexpress LLC m-PEG4-CH2COOH | 16024-66-1 | 99.9% | 5 G
m-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Molecular weight: 266.29
- Formula: C11H22O7
- Appearance: Liquid (density: 1.125 g/cm³)
- Color: Colorless to light yellow
- Shipping at room temperature (in continental US)
- Storage (pure form): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
- In vitro solubility: DMSO: 100 mg/mL
- In vivo solubility: ≥ 2.5 mg/mL in various protocols
Medchemexpress LLC DSPE-PEG-Folate | 1236288-25-7 | MFCD07107414 | 95.7% | 5000 | 5 MG
DSPE-PEG-Folate (MW 5000) is a PEGylated phospholipid in which DSPE is linked to a polyethylene glycol chain terminated with folic acid. It is designed to incorporate into liposomes or nanoparticle surfaces to present folate ligands for receptor-mediated targeting and uptake, and is used in targeted drug delivery, imaging, and nanoparticle functionalization in research settings.
- Facilitates folate-receptor mediated targeting.
- Integrates into lipid bilayers and can form micelles.
- Average molecular weight of 5000 for extended circulation properties.
- High purity (≈95.7%) suitable for research applications.
- Stable as a powder when stored at -20°C for long-term storage.
Medchemexpress LLC Methyltetrazine-PEG8-acid | 2183440-33-5 | MFCD31580146 | 99.0% | C28H44N4O11 | 10MG
Methyltetrazine-PEG8-acid is a PEG8-based linker bearing a methyltetrazine moiety and a terminal carboxylic acid. It is formulated for bioorthogonal tetrazine ligation and conventional amide-coupling chemistries, enabling synthesis of PROTACs, bioconjugates, and labeled probes. The PEG8 spacer improves solubility and reduces steric interference in conjugation reactions.
- Methyltetrazine warhead enables rapid, selective tetrazine ligation
- PEG8 spacer improves aqueous solubility and reduces steric hindrance
- Terminal carboxylic acid is compatible with standard amide coupling
- High purity supports reproducible synthetic workflows
- Supplied in small-scale quantities suitable for research use
Cayman Chemical dPE-PEG 2000-NHS 250mg
A PEGylated derivative of DSPE; has been used in the generation of micelles and in combination with other lipids in the formation of liposomes; intravenous injection of liposomes containing DSPE-PEG(2000)-NHS ester localize to mouse liver and tumor tissue; liposomes containing DSPE-PEG(2000)-NHS ester conjugated to H6 peptide and encapsulating doxorubicin reduce tumor growth in an SK-BR-3 breast cancer mouse xenograft model
Medchemexpress LLC Dspe-peg-biotin | 98.4% | 3400 Da | 25 MG
Biotinylated DSPE-PEG is an amphiphilic PEG-lipid conjugate (average molecular weight 3,400 Da) used to introduce biotin functionality into lipid assemblies. The DSPE lipid anchors the conjugate in bilayers while the PEG spacer presents biotin for high-affinity interactions with streptavidin/avidin. Supplied as a powder for research use, it is commonly applied in targeted delivery, surface functionalization, and assay development.
- Amphiphilic structure enables incorporation into liposomes and micelles.
- Biotin end-group for high-affinity binding to streptavidin/avidin.
- Average molecular weight 3.4 kDa for the PEG spacer.
- High reported purity (~98.4%).
- Available in small powder pack sizes for research use (for example, 25 mg).
- Recommended storage as powder at -20°C to maintain stability.
TARGETMOL CHEMICALS INC POMALIDOMIDE-PEG1-CO2H 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg and bulk. Please contact Fisher for quotes. Pomalidomide-PEG1-CO2H is a synthetic E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker. purity: 97%
LAYSAN BIO INC Maleimide-PEG-Succinimidyl Valarate (MAL-PEG-SVA) molecular weight: 5,000., 1gram
Maleimide-PEG-SVA (Succinimidyl Valerate) is a heterobifunctional combining a maleimide group at one end of the PEG chain and a succinimidyl valerate group at the other. This unique structure allows it to react with both thiol (-SH) and amine (-NH2) groups, making it highly versatile for various bioconjugation applications.
Medchemexpress LLC Pomalidomide-5'-PEG8-C2-COOH | 2138440-78-3 | 98.2% | 697.73 | C32H47N3O14 | 50 MG
Pomalidomide-5'-PEG8-C2-COOH is an E3 ligase ligand-linker conjugate intended as a building block for proteolysis-targeting chimera (PROTAC) synthesis. The molecule combines a pomalidomide-derived warhead with an eight-unit polyethylene glycol (PEG8) spacer and a terminal two-carbon carboxylic acid for coupling, supplied as a high-purity solid for research use.
- Designed for PROTAC construction and E3 ligase engagement.
- Pomalidomide-derived warhead with PEG8 spacer and terminal carboxylic acid for conjugation.
- High reported purity suitable for synthetic applications.
- Soluble in DMSO at high concentration for stock solutions.
- Recommended long-term storage at low temperatures to preserve integrity.
Medchemexpress LLC Tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-Arg(3F-Ph)-PEG2-LGELVWCT) (Cys2-Cys12) | 99.5% | 3488.76 | C152H236FN25O62S2 | 5 MG
This synthetic peptide-GalNAc conjugate is an asialoglycoprotein receptor (ASGPR) ligand intended for lysosome targeting chimera (LYTAC) research. It combines tri-N-acetylgalactosamine units with PEG spacers and a cyclic peptide core to enable ASGPR-mediated uptake of conjugated cargos.
- Is an ASGPR ligand suitable for lysosome targeting chimera research.
- Peptide-based conjugate bearing tri-N-acetylgalactosamine (tri-GalNAc) moieties linked through PEG spacers.
- Molecular weight 3,488.76.
- Purity 99.46% by HPLC.
- Appearance white to off-white solid; hygroscopic in solution.
- Soluble in DMSO at 33.33 mg/mL (9.55 mM); ultrasonic agitation recommended.
- Store at -20°C protected from light; in solvent: -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical use.
Cayman Chemical dPE-PEG 2000 MaleImIde 50mg
A MEK inhibitor (IC50 5.73 nM) and an active metabolite of CI-1040 reduces viral titers in A549 and MDCK cells infected with influenza A (EC50s 6.356 and 4.498 UM respectively) increases survival in H1N1pdm09 influenza A-infected mice at 50 mg/kg per day
STA PHARMACEUTICAL US LLC Fmoc-amino-PEG3-CH2COOH | 100 g | CAS 139338-72-0 | MDL MFCD13182400
Fmoc-amino-PEG3-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 100 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 139338-72-0
- MDL: MFCD13182400
- InChIKey: XNOJSAOJCBOZTA-UHFFFAOYSA-N
- Molecular Weight: 429.469
- Molecular Formula: C23H27NO7
- Purity: ≥95%
- Container Type: 500 mL HDPE
- Pack Size: 100 g
- Net Weight: 100 g
- Gross Weight: 160.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid
- SMILES: O=C(COCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC HyNic-PEG2-DBCO | 2741281-12-7 | N/A | ≥95.0% | C34H38N6O5 | 10MG
HyNic-PEG2-DBCO is a bifunctional PEG-based bioconjugation linker containing a hydrazinonicotinic acid (HyNic) moiety and a dibenzocyclooctyne (DBCO) group. It enables hydrazone formation with aldehyde- or ketone-containing partners and strain-promoted azide-alkyne cycloaddition for copper-free click chemistry, making it suitable for site-selective labeling, antibody conjugation, and PROTAC linker design.
- Enables copper-free click chemistry via DBCO for rapid conjugation
- Supports hydrazone coupling through HyNic to aldehydes and ketones
- PEG2 spacer improves solubility and provides flexible linkage
- Typically supplied with ≥95.0% purity for research use
- Small research-scale packaging suitable for analytical and synthetic workflows
Medchemexpress LLC Bis-PEG4-PFP ester | 1314378-12-5 | 97.0% | 500 MG
Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PROTACs consist of two different ligands connected by a linker.
- One ligand targets an E3 ubiquitin ligase.
- The other ligand targets the protein of interest.
- PROTACs utilize the intracellular ubiquitin-proteasome system.
- Selectively degrade target proteins.
Medchemexpress LLC Mal-amido-PEG6-acid | 1334177-79-5 | 99.3% | 50 MG
Mal-amido-PEG6-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These molecules are designed to exploit the intracellular ubiquitin-proteasome system, selectively degrading target proteins by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Enables targeted protein degradation
- Facilitates connection of E3 ubiquitin ligase and target protein ligands